The most frequently asked question I have received since exposing my journey of using cannabis to treat Lyme disease is what strain of cannabis is best for treating Lyme disease (with the question of which one I used being a close second). Although no one likes to hear this, the answer is unfortunately not so simple, and there is not one definitive answer I can offer. I cannot say with 100% certainty what strain or what dose of any given strain will be the absolute best option for treating any given person’s case of Lyme disease –not because there might be some legal ramifications for offering such advice, but because every case of Lyme disease is highly individualized, so successful treatment of any given case must be highly individualized as well. I can, however, provide brief information that may guide someone looking for the best strain to treat their case of Lyme disease in the right direction.
Choosing a Strain for Lyme Disease: Indica VS. Sativa
Indica: Higher CBD to THC ratio
Sativa: Higher THC to CBD ratio
…most strains are not purely one or the other, but are a mix of the two, and are therefore either Sativa dominant or Indica dominant strains.
Indica dominant strains are the most commonly recommended strains for treating cancer and other conditions commonly treated with cannabis such as epilepsy (which is why you may notice that a large majority of the cannabis oil recipes found online recommend using Indica). However, Lyme disease is once again the exception, as Sativa dominant strains are typically more effective at eradicating the Lyme bacteria. Due to its chemical make-up, most notably the higher amounts of the potent bactericidal THC, Sativa dominant strains are exceptionally effective against elusive, ever evolving, and hard to treat stealth pathogens such as Lyme disease and Lyme co-infections. Indica is not useless in the treatment of Lyme disease though. Not only are all strains beneficial to some degree, but some Indica strains can offer symptomatic relief physically and/or mentally, thereby increasing the odds of successful treatment by allowing the body to place more attention towards healing.
What is my favorite strain of cannabis for treating Lyme, and what strain did I use?
Trainwreck, a close 50/50 mix of Sativa to Indica, was hands down the closest strain to perfection I found for killing bacteria without feeling like I was simultaneously killing myself. While I tried various other strains that were close 50/50 Sativa to Indica and found them highly beneficial as well, I nonetheless favored the results of Trainwreck in particular and thus chose to predominantly use it for treatment, consuming it either in a vaporizer or as a gentle cannabis infused coconut or olive oil.
Note: If, in general, the mental effects of cannabis are not desirable because paranoid events occur etc., then taking the oil along with Indian Pipe tincture (highest recommended dose) right before bed so you can just pass out on it is a possible solution. A mix of ¼ ounce Motherwort tincture, ½ tsp Chinese Skullcap, and ½ tsp Ashwagandha is another option –All help with sleep, especially when working in synergy, but Motherwort and Skullcap are highly specific for combatting fear. Motherwort relaxes the musculature of the brain, thereby reducing physiological holding problems created by fear; and Skullcap is specific for brain/CNS involvement, and can greatly reduce feelings of fear by calming the nervous system. 
Cannabis for Lyme Disease and Related Conditions contains a more in depth look at strains and other aspects pertaining to the use of cannabis as a treatment for Lyme disease, and/or as a tool for symptom picture management throughout the duration of Lyme treatment.
1. Buhner, Stephen H. Healing Lyme Disease Coinfections: Complementary and Holistic Treatments for Bartonella and Mycoplasma. Rochester, VT: Healing Arts Press, 2013.